So far, only one study analysed mGFR changes after BS using the renal clearance of 125I-iothalamate in a cohort of 13 individuals with CKD stage 3 or 4. Therefore GFR changes before and after BS can only be assessed by the measurement of true GFR (mGFR) using the clearance of an exogenous filtration tracer. A randomized control trial is ongoing to analyse the trajectory of the renal function after BS in obese patients with CKD stage 3 or 4 (BOKID, ID-RCB 2014-A011884-43).Įstimation of glomerular filtration rate (eGFR) is biased in obese patients undergoing BS because creatinine and cystatin C productions decrease following lean and fat mass losses. BS might contribute to nephroprotection because it reduces glomerular hyperfiltration, which is an independent factor of renal function loss, improves the adipocytokines profile and induces the remission of hypertension and type 2 diabetes (T2D). Bariatric surgery (BS) is the most effective strategy for a sustained long-term weight loss in morbidly obese individuals. In the United States, 7.4 million people with chronic kidney disease (CKD) are deemed to be severely or morbidly obese, and about 13,000 of them were waitlisted for kidney transplantation between 19. The funder had no role in study design, data collection, decision to publish, or preparation of the manuscript, except in statistical data analysis.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by a grant from the Delegation of Clinical Research and Innovation of University Hospital of Nice “2014”. Received: ApAccepted: AugPublished: August 16, 2021Ĭopyright: © 2021 Grangeon-Chapon et al. PLoS ONE 16(8):Įditor: Petter Bjornstad, University of Colorado Denver School of Medicine, UNITED STATES Citation: Grangeon-Chapon C, Laurain A, Esnault VLM, Cruzel C, Iannelli A, Favre GA (2021) Extracellular fluid volume: A suitable indexation variable to assess impact of bariatric surgery on glomerular filtration rate in patients with chronic kidney disease.
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